Part Used : ราก
Activity : DRUG INTERACTION
Solvent/Active Compound : -
Type of experiment : human
Type of animal : -
Type of study : Cross over
N(Total) : 12*
N(Treatment) : 12
Route : Oral administration
Dose/Conc.(herb) : -
Duration : A single 25-mg dose of warfarin after 7 days' pretreatment with ginseng. Dosing with ginseng was continued for 7 days after administration of the warfarin dose
Type of interaction : P.Kinetics & P.Dynamics
Interaction with drug : Warfarin
Dose/Conc.(drug) : -
Remark : Result: INR and platelet aggregation were not affected by treatment with ginseng. Ginseng did not affect the apparent vols. of distribution or protein binding of warfarin enantiomers. Coadministration of warfarin with ginseng did not affect the pharmacokinetics or pharmacodynamics of either S-warfarin or R-warfarin.
Note : Type of study: open-label, three-way crossover randomized study.
Subject total: Healthy volunteers.
Data incomplete.