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| Thai / English name |
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound :Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 100 microgram/mlDuration : 30 minutesType of interaction : PharmacokineticsInteraction with drug : Docetaxel*/TaxotereDose/Conc.(drug) : -Result : PositiveRemark : - Details of the standardized Ginseng extracts: 0.44% Eleutheroside E, 0.25% Eleutheroside B. - Results: The degree of CYP3A4 inhibition of Ginseng was 16.8%.Note : The effects of complementary and alternative medicine (CAM) on CYP3A4-mediated metabolism of midazolam and docetaxel were determined in human liver microsomes (HLM), using liquid-chromatography coupled to tandem mass spectrometry (LC-MS/MS).
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : 25-hydroxyprotopanaxadiol (25-OH-PPD)Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Docetaxel*/TaxotereDose/Conc.(drug) : -Result : PositiveRemark : Results: In nude mice bearing PC3 xenograft tumors, 25-OH-PPD inhibited tumor growth in a dose dependent manner and could be safely combined with chemotherapeutic agents (taxotere and gemcitabine) and radiation therapy to improve the anti-tumor effects.Note : Data incomplete.
Part Used : เหง้าActivity : DRUG INTERACTIONSolvent/Active Compound : 25-hydroxyprotopanaxadiol (25-OH-PPD)Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Non-specifiedDose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Docetaxel*/TaxotereDose/Conc.(drug) : -Result : NegativeRemark :Note : Data incomplete.
