Part Used : น้ำมันหอมระเหย
Activity : DRUG INTERACTION
Solvent/Active Compound : peppermint oil
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : The essential oils at starting stock concentrations of 128 mg/ml in acetone were combined with ciprofloxacin or amphotericin at a starting stock concentration of 0.01 mg/ml in nine different ratios i.e. 9 : 1; 8 : 2; 7 : 3; 6 : 4; 5 : 5; 4 : 6; 3 : 7; 2 : 8 and 1 : 9.
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Ciprofloxacin
Dose/Conc.(drug) : The essential oils at starting stock concentrations of 128 mg/ml in acetone were combined with ciprofloxacin or amphotericin at a starting stock concentration of 0.01 mg/ml in nine different ratios i.e. 9 : 1; 8 : 2; 7 : 3; 6 : 4; 5 : 5; 4 : 6; 3 : 7; 2 : 8 and 1 : 9.
Remark : The combination profiles for M. piperita (peppermint) essential oil with commercial antimicrobial ciprofloxacin or amphotericin B is presented. Studies on S. aureus show a synergistic pattern for five ratios. Synergy was also noted when tested against K. pneumoniae for four ratios. However, depending on the ratio of the combination, antagonism was noted for four ratios with S. aureus, five ratios with K. pneumoniae and all ratios when tested against C. albicans. The best synergistic profiles noted for K. pneumoniae were closest to and including the 1 : 1 combination.
