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Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Pulegone (PUL)Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 100 mg/kg of PULDuration : -Type of interaction : PharmacokineticsInteraction with drug : BupropionDose/Conc.(drug) : -Result : PositiveRemark : - After the 30 min adaptation period, saline or 1.25, 2.5 or 5 mg/kg of bupropion (BUP) was administered, followed 10 min later by administration of olive oil or 100 or 200 mg/kg of PUL. The ambulatory activity of individual ICR mouse was continuously measured in the following experiments, and the activity during the 60 min after the final administration of the agents was also recorded. Results: PUL and bupropion produced significant ambulation-promoting effects but their statistical interaction was not significant (Two-way ANOVA; effect of PUL F(2, 225) = 8.443, P < 0.05; effect of bupropion, F(3, 225) = 3.981, P < 0.05; their interaction, F(6.225) = 0.375, P > 0.05), indicating that the ambulation-promoting effect of PUL interacts with those of bupropion in an additive manner.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Pulegone (PUL)Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 200 mg/kg of PULDuration : -Type of interaction : PharmacokineticsInteraction with drug : BupropionDose/Conc.(drug) : -Result : PositiveRemark : - After the 30 min adaptation period, saline or 1.25, 2.5 or 5 mg/kg of bupropion (BUP) was administered, followed 10 min later by administration of olive oil or 100 or 200 mg/kg of PUL. The ambulatory activity of individual ICR mouse was continuously measured in the following experiments, and the activity during the 60 min after the final administration of the agents was also recorded. Results: PUL and bupropion produced significant ambulation-promoting effects but their statistical interaction was not significant (Two-way ANOVA; effect of PUL F(2, 225) = 8.443, P < 0.05; effect of bupropion, F(3, 225) = 3.981, P < 0.05; their interaction, F(6.225) = 0.375, P > 0.05), indicating that the ambulation-promoting effect of PUL interacts with those of bupropion in an additive manner.
