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Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : 100% pomelo juiceType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mL/kg of 100% pomelo juiceDuration : Single adminstrationType of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : The tacrolimus blood concentrations of the rat pre-treated with single administration of 100% pomelo juice were significant higher than those pre-treated with water. The AUC value of tacrolimus in the rat pre-treated with 100% pomelo juice was 1.9 times larger than those pre-treated with water.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : 50% pomelo juiceType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mL/kg of 100% pomelo juiceDuration : Single adminstrationType of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : The tacrolimus blood concentrations of the rat pretreated with single administration of 50% pomelo juice were not significantly different from those pre-treated with water.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : 100% pomelo juiceType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mL/kg of 100% pomelo juice dailyDuration : 3 daysType of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : The tacrolimus blood concentrations after administration of 100% pomelo juice for 3 consecutive days was higher, the repeated administration of 100% pomelo juice showed no different profile from single administration.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : 50% pomelo juiceType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 10 mL/kg of 50% pomelo juice dailyDuration : 3 daysType of interaction : PharmacokineticsInteraction with drug : TacrolimusDose/Conc.(drug) : -Result : PositiveRemark : The repeated administration of 50% pomelo juice showed higher tacrolimus blood concentrations than the single administration.
