Part Used : น้ำจากผล
Activity : P-GLYCOPROTEIN STIMULATION
Solvent/Active Compound : 10% Ethyl acetate extract of the juice of Banpeiyu, pomelo I
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : -
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Tacrolimus
Dose/Conc.(drug) : -
Remark : Result: The 10% ethyl acetate extract of the juice of Banpeiyu, pomelo I had little effect on the transcellular transport of tacrolimus or [3H]digoxin across a monolayer of LLC-GA5-COL 150 cells (a porcine kidney epithelial cell line, LLC-PK1, transfected with human MDR1 cDNA and overexpressing human P-glycoprotein).
Note : In conclusion, pomelo constituents inhibit the activity of CYP3A4 and may thereby produce an increase in the blood level of tacrolimus.
Data incomplete