ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : น้ำจากผล

Activity : CYP3A4 INHIBITION

Solvent/Active Compound : 10% Ethyl acetate extract of the juice of Banpeiyu, pomelo I

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : -

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : Tacrolimus

Dose/Conc.(drug) : -

Result : Positive

Remark : Result: The 10% ethyl acetate extract of the juice of Banpeiyu, pomelo I and grapefruit juice (GFJ) significantly inhibited 6beta-hydroxylation of testosterone in human liver microsomes by 76.4 and 83.9%, respectively. The extract of pomelo I was as potent as that of GFJ. The metabolism of tacrolimus itself was also inhibited by the extract of pomelo I, as well as that of GFJ. Furthermore, the inhibition of both 6beta-hydroxylation of testosterone and metabolism of tacrolimus by pomelo I and GFJ was preincubation time-dependent.

Note : In conclusion, pomelo constituents inhibit the activity of CYP3A4 and may thereby produce an increase in the blood level of tacrolimus. Data incomplete

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