ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : น้ำจากผล

Activity : DRUG INTERACTION

Solvent/Active Compound : Furanocoumarins, Fruit juices of 'Guanximiyou' (Citrus grandis Osbeck vs. Guanxi)

Type of experiment : human

Type of animal : -

Type of study : Open trial

N(Total) : 12*

N(Treatment) : 12

Sex : Male

Age : -

Route : Oral administration

Dose/Conc.(herb) : 250 mL of fruit juices of Guanximiyou with 26-mmol (10-mg) plain tablet felodipine.

Duration : Observed for 12 h after administration of drug

Type of interaction : Pharmacokinetics

Interaction with drug : Felodipine

Dose/Conc.(drug) : 26-mmol (10-mg) plain tablet felodipine

Result : Positive

Remark : Results: The geometric mean and 90% confidence intervals of pharmacokinetic parameters for human oral felodipine with C. paradisi, C. grandis Osbeck vs. Guanxi, C. changshanhuyou Y.B. Chang and water were respectively as follows: peak plasma concentration (nmol.bul.L-1), 37 (32-44), 25 (21-29), 19 (16-22) and 18 (15-21); area under the plasma concentration-time curve (nmol.bul.h.bul.L-1), 118 (103-136), 84 (73-97), 64 (56-74) and 59 (51-68). Subjects showed higher heart rates with C. paradisi Macf than with C. changshanhuyou Y.B. Chang or water. *Subject total: Subjects were healthy volunteers.

Note : Data incomplete.

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