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Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : pomelo juiceType of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12N(Treatment) : 12Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : Single oral 200 mg cyclosporine administered with 240 mL of pomelo juice under fasting conditions.Duration : Multiple whole blood samples were collected up to 36 h after each dose.Type of interaction : PharmacokineticsInteraction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyADose/Conc.(drug) : Single oral 200 mg doses of cyclosporineResult : PositiveRemark : Results: Administration of pomelo juice with cyclosporine increased the area under the curve from time 0 to the last measurable concentration (AUCt), area under the curve from time 0 to infinity (AUCinf), and maximum blood concentration (Cmax) of cyclosporine with ratios of least squares means of 119.4% (95% confidence interval [Cl], 113.4%-125.8%, 118.9% (95% Cl, 113.8%-124.3%), and 112.1% (95% Cl, 102.3%-122.8%), respectively. These results suggest that pomelo juice increases the bioavailability of cyclosporine, possibly by inhibiting CYP3A or P-gp activity (or both) in the gut wall.Note : Subject total: healthy volunteers Data incomplete
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : pomelo juiceType of experiment : humanType of animal : -Type of study : Cross overN(Total) : 12N(Treatment) : 12Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : Single oral 200 mg cyclosporine administered with 240 mL of pomelo juice under fasting conditions.Duration : Multiple whole blood samples were collected up to 36 h after each dose.Type of interaction : PharmacokineticsInteraction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyADose/Conc.(drug) : Single oral 200 mg doses of cyclosporineResult : PositiveRemark : Results: Administration of pomelo juice with cyclosporine increased the area under the curve from time 0 to the last measurable concentration (AUCt), area under the curve from time 0 to infinity (AUCinf), and maximum blood concentration (Cmax) of cyclosporine with ratios of least squares means of 119.4% (95% confidence interval [Cl], 113.4%-125.8%, 118.9% (95% Cl, 113.8%-124.3%), and 112.1% (95% Cl, 102.3%-122.8%), respectively. These results suggest that pomelo juice increases the bioavailability of cyclosporine, possibly by inhibiting CYP3A or P-gp activity (or both) in the gut wall.Note : Subject total: healthy volunteers Data incomplete
