Part Used : น้ำจากผล
Activity : EFFECTS ON PHARMACOKINETIC
Solvent/Active Compound : orange juice
Type of experiment : human
Type of animal : -
Type of study : Cross over
N(Total) : 12*
N(Treatment) : 12
Route : Oral administration
Dose/Conc.(herb) : a single oral dose of diltiazem 180 mg with 200 mL of orange juice
Duration : -
Type of interaction : P.Kinetics & P.Dynamics
Interaction with drug : Diltiazem
Dose/Conc.(drug) : 180 mg
Remark : Results: The 90% Cl of the Cmax ratios for orange juice/water were 104.59 - 114.86. Similarly, the 90% Cl of the AUC0-infinity ratios for orange juice vs. water were 103.68 - 119.83. Since these values fall within the bioequivalence criteria of 80 - 120% limits, the study demonstrates absence of interaction of diltiazem with orange juice.
Note : *Subject total: Subjects were healthy volunteers.
Conclusions: There is no significant influence of grape juice or orange juice on the pharmacokinetics and pharmacodynamics of diltiazem.
Data incomplete.