Part Used : น้ำจากผล
Activity : EFFECTS ON PHARMACOKINETIC
Solvent/Active Compound : -
Type of experiment : human
Type of animal : -
Type of study : Cross over
N(Total) : 10*
N(Treatment) : 10
Route : Oral administration
Dose/Conc.(herb) : *
Duration : *
Type of interaction : Pharmacokinetics
Interaction with drug : Atenolol
Dose/Conc.(drug) : 50 mg
Remark : - Orange juice decreased the mean peak plasma concn. (Cmax) of atenolol by 49% (range 16-59%, P <0.01), and the mean area under the plasma atenolol concn.-time curve (AUCo-33h) by 40% (range 25-55%; P<0.01). The time of the peak concn. (tmax) and the elimination half-life (t1/2) of atenolol remained unchanged by orange juice. The amt. of atenolol excreated into urine was decreased by 38% (range 17-60%, P<(0.01), but the renal clearance remained unaltered.
- Orange juice moderately interferes with the gastrointestinal absorption of atenolol.
Note : Data incomplete
*In randomized cross-over study with two phases and a washout of 2 wk, ten healthy volunteers took either 200 mL orange juice or water thrice daily for 3 days and twice on the fourthy day. On the morning of day 3, each subject ingested 50 mg atenolol with an addnl. amt. of either 200 mL orange juice or water.
