ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : น้ำจากผล

Activity : DRUG INTERACTION

Solvent/Active Compound : ethyl acetate extracts of orange juice

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of the ethyl acetate extracts of orange juice (diluted to be equivalent to 50% of the original orange juice strength).

Duration : 60 min.

Type of interaction : Pharmacokinetics

Interaction with drug : Phenylalanine*/L-phenylalanine

Dose/Conc.(drug) : 500 nM [14C]phenylalanine

Result : Negative

Remark : Result: No significant effect on the uptake of [14C]phenylalanine by Coaco-2 cells was found, compared with the control. This finding indicated that the effect is specific to the vinblastine efflux transporter.

---