Part Used : น้ำจากผล
Activity : EFFECTS ON PHARMACOKINETIC
Solvent/Active Compound : ethyl acetate extracts of orange juice
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of the ethyl acetate extracts of orange juice (diluted to be equivalent to 50% of the original orange juice strength).
Duration : 60 min.
Type of interaction : Pharmacokinetics
Interaction with drug : Phenylalanine*/L-phenylalanine
Dose/Conc.(drug) : 500 nM [14C]phenylalanine
Remark : Result: No significant effect on the uptake of [14C]phenylalanine by Coaco-2 cells was found, compared with the control. This finding indicated that the effect is specific to the vinblastine efflux transporter.