Part Used : น้ำจากผล
Activity : P-GLYCOPROTEIN INHIBITION
Solvent/Active Compound : Methanol elutes of ethyl acetate extracts of orange juice
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of the methanol elutes of ethyl acetate extracts of orange juice.
Duration : 60 min.
Type of interaction : Pharmacokinetics
Interaction with drug : Vincristine*/VCR/LCR/Leurocristine
Dose/Conc.(drug) : 10 nM [3H]vinblastine
Remark : Result: the 60, 70, and 80% methanol eluates caused large increases of [3H}vinblastine uptake, these fractions seemed to contain the major inhibitor of P-gp.
