Part Used : น้ำจากผล
Activity : EFFECTS ON PHARMACOKINETIC
Solvent/Active Compound : fruit juice
Type of experiment : human
Type of animal : -
Type of study : Cross over
N(Total) : 10* (M/F = 7/3)
N(Treatment) : 10 (M/F = 7/3)
Sex : Both sex
Age : 19-29 yrs.
Route : Oral administration
Dose/Conc.(herb) : Subjects ingested 200 mL normal-strength orange juice 3 times a day for 2 days. On the morning of day 3, 1 hour after ingestion of 200 mL orange juice, each subject ingested 100 mg celiprolol with 200 mL orange juice. In addition, 200 mL orange juice was ingested at 4, 10, 22, and 27 hours after celiprolol intake. The concentrations of celiprolol in plasma and its excretion into urine were measured up to 33 hours after its dosing. Systolic and diastolic blood pressures and heart rate were recorded up to 10 hours.
Duration : 4 days and a washout of 2 weeks
Type of interaction : Non-specified
Interaction with drug : Celiprolol
Dose/Conc.(drug) : 100 mg celiprolol
Remark : Result: Orange juice reduced the mean peak plasma concentration of celiprolol by 89% (P < .01) and the mean area under the plasma celiprolol concentration-time curve by 83% (P < .01). The time to peak concentration of celiprolol increased from 4 to 6 hours (P < .05), and the half-life was prolonged from 4.6 to 10.8 hours (P = .05) after ingestion of orange juice. Orange juice reduced the urnary excretion of celiprolol by 77% (p < .01). No significant differences were observed in the hemodynamic variables between the phases.
Note : Subject total: Subjects were healthy volunteers
