Synonym |
Thai / English name |
Part Used : น้ำจากผลActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : Methanol elutes of ethyl acetate extracts of orange juiceType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of the methanol elutes of ethyl acetate extracts of orange juice.Duration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 10 nM [3H]vinblastineResult : PositiveRemark : Result: the 60, 70, and 80% methanol eluates caused large increases of [3H}vinblastine uptake, these fractions seemed to contain the major inhibitor of P-gp.
Part Used : น้ำจากผลActivity : P-GLYCOPROTEIN INHIBITIONSolvent/Active Compound : 70% Methanol elutes of ethyl acetate extracts of orange juiceType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of the 70% methanol elutes of ethyl acetate extracts of orange juice.Duration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 10 nM [3H]vinblastineResult : PositiveRemark : Result: The 70% methanol eluate was applied to a silica gel column and eluted with hexane/acetone (5:1, 3:1, 1:1) and chloroform/methanol (1:1). The highest P-gp-inhibitory activity was found in the fourth fraction eluted with hexane/acetone (3:1).
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : 3,3'4',5,6,7,8-heptamethoxyflavone (HMF)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of HMF 0.1, 1, 10, 100 microMDuration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 10 nM [3H]vinblastineResult : PositiveRemark : Result: The steady-state uptake of [3H]vinblastine by Caco-2 cells was increased by HMF in a concentration-dependent manner, and the uptakes amounted to 578 +/- 15.9% of the control, in the presence of 50 microM methoxyflavones.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : 3,3'4',5,6,7,8-heptamethoxyflavone (HMF)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of HMF 0.1, 1, 10, 100 microMDuration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 10 nM [3H]vinblastineResult : PositiveRemark : Result: The steady-state uptake of [3H]vinblastine by Caco-2 cells was increased by HMF in a concentration-dependent manner, and the uptakes amounted to 578 +/- 15.9% of the control, in the presence of 50 microM methoxyflavones.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : tangeretinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of tangeretin 0.1, 1, 10, 100 microMDuration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 10 nM [3H]vinblastineResult : PositiveRemark : Result: The steady-state uptake of [3H]vinblastine by Caco-2 cells was increased by tangeretin in a concentration-dependent manner, and the uptakes amounted to 906 +/- 23.6% of the control, in the presence of 50 microM methoxyflavones.
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : tangeretinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of tangeretin 0.1, 1, 10, 100 microMDuration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 10 nM [3H]vinblastineResult : PositiveRemark : Result: The steady-state uptake of [3H]vinblastine by Caco-2 cells was increased by tangeretin in a concentration-dependent manner, and the uptakes amounted to 906 +/- 23.6% of the control, in the presence of 50 microM methoxyflavones.
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : nobiletinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of nobiletin 0.1, 1, 10, 100 microMDuration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 10 nM [3H]vinblastineResult : PositiveRemark : Result: The steady-state uptake of [3H]vinblastine by Caco-2 cells was increased by nobitetin in a concentration-dependent manner, although less potently than by HMF or tangeretin.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : nobiletinType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 10 nM [3H]vinblastine in the presence of nobiletin 0.1, 1, 10, 100 microMDuration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 10 nM [3H]vinblastineResult : PositiveRemark : Result: The steady-state uptake of [3H]vinblastine by Caco-2 cells was increased by nobitetin in a concentration-dependent manner, although less potently than by HMF or tangeretin.
Part Used : น้ำจากผลActivity : EFFECTS ON PHARMACOKINETICSolvent/Active Compound : 3,3',4',5,6,7,8-heptamethoxyflavone (HMF)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 20 mM [3H]vinblastine in the presence of HMF 20 microMDuration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 20 mM [3H]vinblastineResult : PositiveRemark : Result: In LLC-PK1 cells, the uptake of [3H]vinblastine at steady state was not influenced by 10 mM cyclosporin A, HMF, tangeretin, or nobiletin.
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : 3,3',4',5,6,7,8-heptamethoxyflavone (HMF)Type of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : Uptake experiments were performed in 250 ml of incubation buffer containing 20 mM [3H]vinblastine in the presence of HMF 20 microMDuration : 60 min.Type of interaction : PharmacokineticsInteraction with drug : Vinblastine*/VLBDose/Conc.(drug) : 20 mM [3H]vinblastineResult : PositiveRemark : Result: In LLC-PK1 cells, the uptake of [3H]vinblastine at steady state was not influenced by 10 mM cyclosporin A, HMF, tangeretin, or nobiletin.