Part Used : ไม่ระบุ
Activity : DRUG INTERACTION
Solvent/Active Compound : -
Type of experiment : human
Type of animal : -
Type of study : Case report
N(Total) : 1 (M/F = 0/1)
N(Treatment) : 1 (M/F = 0/1)
Route : Oral administration
Dose/Conc.(herb) : 4 tablets of Aloe vera / day
Duration : 2 weeks
Type of interaction : Pharmacodynamics
Interaction with drug : Sevoflurane
Dose/Conc.(drug) : 0.5-1.3%
Remark : Compounds contained within Aloe vera can cause a reduction in prostaglandin synthesis, which may inhibit secondary aggregation of platelets. Sevoflurane inhibits thromboxane A2 formation by suppression of cyclooxygenase activity, impairs platelet aggregation, and prolongs bleeding. Although the vascularity and size of the hemangioma were the most important factors for the massive intraoperative blood loss, concomitant use of sevoflurane and Aloe vera played a contributory role. An objective causality assessment revealed that this adverse event was possible as a result of the sevoflurane and Aloe vera interaction.
