ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ใบ

Activity : DRUG INTERACTION

Solvent/Active Compound : Aloe vera juice

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : -

Duration : 7 days

Type of interaction : Pharmacokinetics

Interaction with drug : Buspirone

Dose/Conc.(drug) : -

Result : Positive

Remark : Rats were pretreated with Aloe vera juice for 7 days. The probe drug (buspirone) solution was placed in the isolated intestinal sac. Samples were collected at preset time points and replaced with fresh buffer. The drug content in the samples was estimated using high performance liquid chromatography medthod. The results reveal that there was a significant (p < 0.05) difference compared to control, in the transport of buspirone from the intestinal sacs which were pretreated with Aloe vera juice. It suggests that Aloe vera might be acting by inhibiting the transporters and enzymes which are responsible for transport/metabolism of buspirone.

Note : Data incomplete Type of experiment: Rat intestine

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