Part Used : เหง้า
Activity : ANALGESIC ACTIVITY
Solvent/Active Compound : Hydroalcoholic extract of Acorus calamus (HAE-AC)
Type of experiment : in vivo
Type of animal : rat
N(Total) : -
N(Treatment) : -
Route : Oral administration
Dose/Conc.(herb) : HAE-AC 200 mg/kg
Duration : 14 consecutive days.
Type of interaction : Pharmacodynamics
Interaction with drug : Vincristine*/VCR/LCR/Leurocristine
Dose/Conc.(drug) : 50 microgram/kg, i.p. for 10 consecutive days
Remark : Result: Vincristine administration produced significant histopathological changes assessed in transverse sections of the sciatic nerve; nerve derangement, axonal swelling, and increases in numbers of Schwann and satellite cells were noted. Pre-tretment with the hydroalcoholic extract of AC (100 and 200 mg/kg; p.o.) significantly attenuated vincristine-induced axonal degeneration and other histopathological alterations.
