| Synonym |
| Thai / English name |
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : aqueous extractType of experiment : in vivoType of animal : rabbitType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : GliclazideDose/Conc.(drug) : -Result : NegativeRemark : Type of animal: normal and rabbits. Results: Fenugreek-seed powder extract produced hypoglycemia when given alone and prolonged the effect of gliclazide in combination during 1-12 h in normal and diabetic rats and during 2-8 h in normal rabbits without hypoglycemic convulsions.Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : Ethanolic extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 500 mg/kgDuration : 30 daysType of interaction : PharmacokineticsInteraction with drug : Daonil*/Glyburide/Glibenclamide/Diadeta/Glybenclamide/GlybenzcyclamideDose/Conc.(drug) : -Result : NegativeRemark : The effects of Trigonella foenum graecum were moderate when administered either individually or in combination with glibenclamide against diabetic and non-diabetic rats.Note : Data incomplete
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : water extractType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : 200 mg/kgDuration : -Type of interaction : PharmacokineticsInteraction with drug : GlimepirideDose/Conc.(drug) : 5-20 mg/kgResult : NegativeRemark : The combination of water extract and lower dose of glimepiride (5 mg/kg) has shown safer and potent hypoglycemic as well as antihyperglycemic activity and not created severe hypoglycemia in normal rats, while higher doses (200 mg/kg of water extract and 10 and 20 mg/kg of glimepiride) were generated lethal hypoglycemia in normal rats.Note : Data incomplete
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : dogType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 25 g twice dailyDuration : 7 dayType of interaction : PharmacokineticsInteraction with drug : Theophylline*/AminophyllineDose/Conc.(drug) : 200 mgResult : PositiveRemark : Treatment with fenugreek (25 g, orally) lead to a decrease in Cmax and AUCo-t of theophylline of about 28% and 22%, respectively, with no significant changes in T1/2lambda compared with the baseline values.Note : Data incomplete. Beagle dogs received theophylline on first day following with herb for 7 day and on eighth day, theophylline was re-administrated again.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : dogType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 7.5 g twice dailyDuration : 7 dayType of interaction : PharmacokineticsInteraction with drug : Theophylline*/AminophyllineDose/Conc.(drug) : 200 mgResult : NegativeRemark : Treatment with fenugreek (25 g, orally) lead to a decrease in Cmax and AUCo-t of theophylline of about 28% and 22%, respectively, with no significant changes in T1/2lambda compared with the baseline values.Note : Data incomplete. Beagle dogs received theophylline on first day following with herb for 7 day and on eighth day, theophylline was re-administrated again.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : dogType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 2.5 g twice dailyDuration : 7 dayType of interaction : PharmacokineticsInteraction with drug : Theophylline*/AminophyllineDose/Conc.(drug) : 200 mgResult : NegativeRemark : Treatment with fenugreek (25 g, orally) lead to a decrease in Cmax and AUCo-t of theophylline of about 28% and 22%, respectively, with no significant changes in T1/2lambda compared with the baseline values.Note : Data incomplete. Beagle dogs received theophylline on first day following with herb for 7 day and on eighth day, theophylline was re-administrated again.
