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LEGUMINOSAE (FABACEAE) - PAPILIONIODEAE Trigonella foenum-graecum L.

Synonym

none ...

Thai / English name

ลูกซัด*

[1-2] of 2 article(s) found

หน้า 1

[1] COMPLEMENTARY AND COMPARATIVE STUDY ON HYPOGLYCEMIC AND ANTIHYPERGLYCEMIC ACTIVITY OF VARIOUS EXTRACTS OF EUGENIA JAMBOLANA SEED, MOMORDICA CHARANTIA FRUITS, GYMNEMA SYLVESTRE, AND TRIGONELLA FOENUM GRAECUM SEEDS IN RATS.
MUKESH YADAV,AMITA LAVANIA,RADHA TOMAR,ET AL.
APPL BIOCHEM BIOTECHNOL 2010 Vol.160(),2388-400 $41419 [Full]

Part Used : เมล็ด
Activity : DRUG INTERACTION

Solvent/Active Compound : Water extract

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 200 mg/kg bw

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Glimepiride
Dose/Conc.(drug) : 20 mg/kg bw

Result : Positive

Remark : Normal rats

Part Used : เมล็ด
Activity : DRUG INTERACTION

Solvent/Active Compound : Water extract

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 200 mg/kg bw

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Glimepiride
Dose/Conc.(drug) : 10 mg/kg bw

Result : Positive

Remark : Normal rats

Part Used : เมล็ด
Activity : DRUG INTERACTION

Solvent/Active Compound : Water extract

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 200 mg/kg bw

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Glimepiride
Dose/Conc.(drug) : 5 mg/kg bw

Result : Positive

Remark : Normal rats

Part Used : เมล็ด
Activity : DRUG INTERACTION

Solvent/Active Compound : Water extract

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 200 mg/kg bw

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Glimepiride
Dose/Conc.(drug) : 20 mg/kg bw

Result : Positive

Remark : Hyperglycemic rats

Part Used : เมล็ด
Activity : DRUG INTERACTION

Solvent/Active Compound : Water extract

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 200 mg/kg bw

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Glimepiride
Dose/Conc.(drug) : 10 mg/kg bw

Result : Positive

Remark : Hyperglycemic rats

Part Used : เมล็ด
Activity : DRUG INTERACTION

Solvent/Active Compound : Water extract

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 200 mg/kg bw

Duration : -
Type of interaction : Pharmacodynamics

Interaction with drug : Glimepiride
Dose/Conc.(drug) : 5 mg/kg bw

Result : Positive

Remark : Hyperglycemic rats

[2] COMPLEMENTARY HYPOGLYCEMIC AND ANTI-HYPERGLYCEMIC ACTIVITY OF VARIOUS EXTRACTS OF FENUGREEK SEEDS IN RATS.
YADAV M,TOMAR R,PRASAD G,ET AL.
ASIAN J BIOCHEM 2008 Vol.3(3),182-7 420845 [Abstract]

Part Used : เมล็ด
Activity : DRUG INTERACTION

Solvent/Active Compound : water extract

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 200 mg/kg

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Glimepiride
Dose/Conc.(drug) : 5-20 mg/kg

Result : Negative

Remark : The combination of water extract and lower dose of glimepiride (5 mg/kg) has shown safer and potent hypoglycemic as well as antihyperglycemic activity and not created severe hypoglycemia in normal rats, while higher doses (200 mg/kg of water extract and 10 and 20 mg/kg of glimepiride) were generated lethal hypoglycemia in normal rats.

Note : Data incomplete

หน้า 1

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