ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ไม่ระบุ

Activity : DRUG INTERACTION

Solvent/Active Compound : (-)-hydnocarpin

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Non-specified

Dose/Conc.(herb) : *

Duration : 2 h incubation

Type of interaction : Pharmacokinetics

Interaction with drug : Vincristine*/VCR/LCR/Leurocristine

Dose/Conc.(drug) : -

Result : Positive

Remark : *Dose: vincristine at 1.5 nM and 0.75 nM combined with (-)-hydnocarpin at 10 and 5 nM in the 697 cells, a multidrug-resistant cell line. Result: When combined with (-)-hydnocarpin at concentrations of 10 and 5 mM, vincristine-mediated growth inhibition in the 697-R cells increased significantly over the sum of the individual agents to 72% (p

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