ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : น้ำจากผล

Activity : DRUG INTERACTION

Solvent/Active Compound : -

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : -

Duration : 8 days

Type of interaction : Pharmacokinetics

Interaction with drug : Phenytoin*/Diphenylhydantoin/DPH

Dose/Conc.(drug) : -

Result : Positive

Remark : Noni juice pretreated rats decreased the bioavailability of phenytoin by 2.81 fold when compared with control.

Note : - Pretreatment 7 days with noni juice or Ginkgo biloba, on day 8 the phenytoin was co-administrered orally with noni juice or Ginkgo biloba and the serum pharmacokinetics were determined at various time options (1, 2, 4, 6, 8, 12 and 24 hours) by HPLC. - Data incomplete

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