ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ผล

Activity : DRUG INTERACTION

Solvent/Active Compound : Kuguacin J

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : 5 and 10 micromolar of kuguacin J

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : Paclitaxel*/Taxol/PTX

Dose/Conc.(drug) : -

Result : Positive

Remark : Co-administration of 5 and 10 micromolar of kuguacin J enhanced the response of KB-V1 cells to vinblastine and paclitaxel, 1.9- and 4.3-fold respectively, for vinblastine, and 1.9- and 3.2-fold respectively, for paclitaxel. The experimental data demonstrated that kuguacin J inhibits the transport activity of p-glycoprotein by directly interacting with substrate binding site of p-glycoprotein.

Note : Data from review

---