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OLEACEAE Olea europaea L.

Synonym

none ...

Thai / English name

มะกอกฝรั่ง*

[1-1] of 1 article(s) found

หน้า 1

[1] OLEUROPEIN PREVENTS DOXORUBICIN-INDUCED CARDIOMYOPATHY INTERFERING WITH SIGNALING MOLECULES AND CARDIOMYOCYTE METABOLISM.
ANDREADOU,IOANNA;MIKROS,EMMANUEL;IOANNIDIS,KONSTANTINOS;ET AL.
J MOL CELL CARDIOL 2014 Vol.69(),4-16 $57887 [Full]

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : Oleuropein

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Intraperitoneal
Dose/Conc.(herb) : 1000 mg/kg

Duration : 14 days
Type of interaction : Pharmacokinetics

Interaction with drug : Doxorubicin*/Adrimycin/ADR/Adria
Dose/Conc.(drug) : 18 mg/kg

Result : Positive

Remark : Oleuropein prevented DXR-induced cardiomyopathy.

Note : Type of experiment: The rats were divided into 6 groups: Control gruop (normal saline); OLEU-1 (1000 mg/kg of oleuropein); OLEU-2 (2000 mg/kg of oleuropein); doxorubicin (DXR) group (18 mg/kg). OLEU group and DXR group were given i.p. into 6 equal doses administered over a period of 2 weeks. DXR-OLEU-1 and DXR-OLEU-2 groups were injected with OLEU and DXR for 2 weeks as indicated above.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : Oleuropein

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Intraperitoneal
Dose/Conc.(herb) : 2000 mg/kg

Duration : 14 days
Type of interaction : Pharmacokinetics

Interaction with drug : Doxorubicin*/Adrimycin/ADR/Adria
Dose/Conc.(drug) : 18 mg/kg

Result : Positive

Remark : Oleuropein prevented DXR-induced cardiomyopathy.

Note : Type of experiment: The rats were divided into 6 groups: Control gruop (normal saline); OLEU-1 (1000 mg/kg of oleuropein); OLEU-2 (2000 mg/kg of oleuropein); doxorubicin (DXR) group (18 mg/kg). OLEU group and DXR group were given i.p. into 6 equal doses administered over a period of 2 weeks. DXR-OLEU-1 and DXR-OLEU-2 groups were injected with OLEU and DXR for 2 weeks as indicated above.

หน้า 1

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