Part Used : ไม่ระบุ
Activity : MEMORY ENHANCEMENT EFFECT
Solvent/Active Compound : -
Type of experiment : in vivo
Type of animal : rat
N(Total) : -
N(Treatment) : -
Route : Oral administration
Dose/Conc.(herb) : 100 mg/kg
Duration : 42 days
Type of interaction : P.Kinetics & P.Dynamics
Interaction with drug : Rivastigmine
Dose/Conc.(drug) : 5 mg/kg, p.o.
Remark : Results: B. monniera, rivastigmine, and a combination of B. monniera and rivastigmine could be highly beneficial in preventing the learning and memory impairment induced by chronic administration of AlCl3. However, the combination of B. monniera (Bacopa) with rivastigmine was found to be more effective than either treatment alone in preventing AlCl3-induced learning and memory deficits.
Note : Type of experiment: rats were randomized into 10 groups (G1-G10). The animals in G1 were treated with vehicle and served as controls. Animals in G2 and G7 were treated with 5 mg/kg rivastigmine p.o., G3 and G8 with 100 mg/kg B. monniera p.o., G4 and G9 with 200 mg/kg B. monniera p.o., and G5 and G10 with a combination of 5 mg/kg rivastigmine and 100 mg/kg B. monniera p.o. along with their assigned drug treatments, the animals in G7, G8, G9, and G10 were challenged with AlCl3 (100 mg/kg p.o.) daily for 42 days to induce learning deficits and amnesia; animals in G6 served as positive controls and only reveived AlCl3.
