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Part Used : เมล็ด

Activity : CYP3A4 INHIBITION

Solvent/Active Compound : neferine

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : -

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : Testosterone

Dose/Conc.(drug) : -

Result : Positive

Remark : Result: Neferine showed a significant mechanism-based inhibition of CYP3A4. Neferine displayed Pi bonds with the heme group of CYP3A4, which may produce a mechanism-based inhibition by the heme group pathway. Combined with the CYP3A4 substrate, it is reasonable to believe that Nef has a mixed-type inhibition or positive cooperativity of CYP3A4 mediated testosterone metabolism.

Note : Phenacetin, dextromethorphan and testosterone, respectively, were used as CYP1A2, CYP2D6 and CYP3A4 substrates, and their metabolites were determined by validated HPLC methodologies.

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