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Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 56 (M/F = 24/32)N(Treatment) : 2Sex : Both sexAge : 68.7 +/- 7.7 yrsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Amlodipine*/AmlopineDose/Conc.(drug) : -Result : PositiveRemark : บัวบกมีฤทธิ์ยับยั้งเอนไซม์ CYP3A4, CYP1A4 ทำให้ยาที่เมตาบอไลซ์ผ่านเอนไซม์เหล่านี้ถูกแปรสถาพลดลง ทำให้ระดับยาในเลือดสูงขึ้นNote : Data incomplete, data from review article
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : madecassosideType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100 mg/kgDuration : single doseType of interaction : PharmacokineticsInteraction with drug : DigoxinDose/Conc.(drug) : -Result : PositiveRemark :Note : The combination with either digoxin or probenecid significantly attenuated the excretion of madecassoside as parent from bile, indicating that P-glycoprotein and multi drug resistance associated protein might contribute to the hepatobiliary elimination of madecassoside.
Part Used : -Activity : DRUG INTERACTIONSolvent/Active Compound : madecassosideType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 100 mg/kgDuration : single doseType of interaction : PharmacokineticsInteraction with drug : Probenecid*/BenemidDose/Conc.(drug) : -Result : PositiveRemark :Note : The combination with either digoxin or probenecid significantly attenuated the excretion of madecassoside as parent from bile, indicating that P-glycoprotein and multi drug resistance associated protein might contribute to the hepatobiliary elimination of madecassoside.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Valproic acid*/Valproate/Sodium valproate/Valproate sodium/2-propylpentanoic acid/Dipropylacetic acidDose/Conc.(drug) : -Result : PositiveRemark : A combination of Centalla asiatica (CA) extract with antiepileptic drugs (AEDs) resulted in a reduction in the ED50 of CA extract and concomitant AEDS. The ED50 of intraperitoneally given phyenytoin, valproate and gabapentin, were found to be 13, 14, and 310 mg/kg BW, respectively, when given alone, whereas the corresponding values in the presence of CA extract were 5, 29 and 79 mg/kg BW.Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : GabapentinDose/Conc.(drug) : -Result : PositiveRemark : A combination of Centalla asiatica (CA) extract with antiepileptic drugs (AEDs) resulted in a reduction in the ED50 of CA extract and concomitant AEDS. The ED50 of intraperitoneally given phyenytoin, valproate and gabapentin, were found to be 13, 14, and 310 mg/kg BW, respectively, when given alone, whereas the corresponding values in the presence of CA extract were 5, 29 and 79 mg/kg BW.Note : Data incomplete
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Phenytoin*/Diphenylhydantoin/DPHDose/Conc.(drug) : -Result : PositiveRemark : A combination of Centalla asiatica (CA) extract with antiepileptic drugs (AEDs) resulted in a reduction in the ED50 of CA extract and concomitant AEDS. The ED50 of intraperitoneally given phyenytoin, valproate and gabapentin, were found to be 13, 14, and 310 mg/kg BW, respectively, when given alone, whereas the corresponding values in the presence of CA extract were 5, 29 and 79 mg/kg BW.Note : Data incomplete
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 500 mg/kgDuration : The anticonvulsant activity was assessed by the classical Maximal Electro Shock (MES) test at 1, 3, 6 and 24 h after drug administration.Type of interaction : PharmacodynamicsInteraction with drug : Phenytoin*/Diphenylhydantoin/DPHDose/Conc.(drug) : -Result : EquivocalRemark : Results: When Centella asiatica (CA) was combined with phenytoin, though seizure protection was seen, this effect was not statistically significant. When CA was combined with phenobarbitone, the protective activity of phenobarbitone declined from 50% to 0% (p < 0.05) at 3 h. When CA was combined with carbamazepine, significant seizure protection was seen only at 1 and 3 h (p < 0.05).Note : Data incomplete.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 500 mg/kgDuration : The anticonvulsant activity was assessed by the classical Maximal Electro Shock (MES) test at 1, 3, 6 and 24 h after drug administration.Type of interaction : PharmacodynamicsInteraction with drug : Pentobarbital*/PentobarbitoneDose/Conc.(drug) : -Result : PositiveRemark : Results: When Centella asiatica (CA) was combined with phenytoin, though seizure protection was seen, this effect was not statistically significant. When CA was combined with phenobarbitone, the protective activity of phenobarbitone declined from 50% to 0% (p < 0.05) at 3 h. When CA was combined with carbamazepine, significant seizure protection was seen only at 1 and 3 h (p < 0.05).Note : Data incomplete.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 500 mg/kgDuration : The anticonvulsant activity was assessed by the classical Maximal Electro Shock (MES) test at 1, 3, 6 and 24 h after drug administration.Type of interaction : PharmacodynamicsInteraction with drug : Carbamazepine*/CBZDose/Conc.(drug) : -Result : PositiveRemark : Results: When Centella asiatica (CA) was combined with phenytoin, though seizure protection was seen, this effect was not statistically significant. When CA was combined with phenobarbitone, the protective activity of phenobarbitone declined from 50% to 0% (p < 0.05) at 3 h. When CA was combined with carbamazepine, significant seizure protection was seen only at 1 and 3 h (p < 0.05).Note : Data incomplete.
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : asiaticosideType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacodynamicsInteraction with drug : Vincristine*/VCR/LCR/LeurocristineDose/Conc.(drug) : -Result : PositiveRemark : - MTT assay was used to evaluate inhibitory effect of asiaticoside combined with vincristine on proliferation of several cancer cell lines, including KB, KBv200, MCF-7, and MCF-7/ADM. - The apoptosis rates were much higher in asiaticoside plus vincristine groups than in vincristine or asiaticoside groups. Bcl-2 phosphorylation levels were higher in the combination groups than in vincristine of asiaticoside alone groups. The activated caspase-3 protein was only presented in the combination groups. Asiaticoside plus vincristine enhanced S-G(2)/M arrest, up-reglulated Cyclin B1 protein expression, and down-regulated P34 (cdc2) protein expression in KB cells.Note : Data incomplete.
