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Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : madecassic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : - IC50 = > 250 microgram/ml (> 495.3 micromolar)Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : asiaticoside, asiatic acid and madecassic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : Centella asiatica (CA) extracts and active constituents inhibited CYP2C9, CYP2D6 and CYP3A4 activities with varying potency with CYP2C9 being the most susceptible isoform to inhibition. Significant inhibition was observed for asiatic acid and CA ethanol and dichloromethane extracts, implying involvement of semipolar constituents from CA in the effect. This study suggested that CA could cause drug-herb interactions through CYP2C9 inhibitiont.
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : aqueousType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : - IC50 = 615.1 microgram/ml
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : ethanolType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : - IC50 = 61.2 microgram/ml
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : dichloromethaneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : - IC50 = 30.2 microgram/ml - Moderate inhibition was observed with C. asiatica dichloromethane extract. Therefore care should be taken when these C. asiatica components are co-administered with CYP2C19 substrates (such as omeprazole, proguanil, barbiturates, citalopram, and diazepam)
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : hexaneType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : - IC50 = 112.5 microgram/ml
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : asiatic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : - IC50 = 117.5 microgram/ml (240.4 micromolar)
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : asiaticosideType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : - IC50 = 408.3 microgram/ml (425.7 micromolar)
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : madecassic acidType of experiment : in vitroType of animal : -Type of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : -Dose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : -Dose/Conc.(drug) : -Result : PositiveRemark : - IC50 = 92.5 microgram/ml (183.3 micromolar)
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 56 (M/F = 24/32)N(Treatment) : 2Sex : Both sexAge : 68.7 +/- 7.7 yrsRoute : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Enalapril*/EnalaprilatDose/Conc.(drug) : -Result : PositiveRemark : บัวบกมีฤทธิ์ยับยั้งเอนไซม์ CYP3A4, CYP1A4 ทำให้ยาที่เมตาบอไลซ์ผ่านเอนไซม์เหล่านี้ถูกแปรสถาพลดลง ทำให้ระดับยาในเลือดสูงขึ้นNote : Data incomplete, data from review article
