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UMBELLIFERAE (APIACEAE) Centella asiatica (L.) Urb.

Synonym

none ...

Thai / English name

บัวบก*

[1-1] of 8 article(s) found

หน้า 1 2 3 4

[1] IN VITRO MODULATORY EFFECTS ON THREE MAJOR HUMAN CYTOCHROME P450 ENZYMES BY MULTIPLE ACTIVE CONSTITUENTS AND EXTRACTS OF CENTELLA ASIATICA.
PAN Y,ABD-RASHID BA,ISMAIL Z,ET AL.
J ETHNOPHARMACOL 2010 Vol.130(),275-83 $31097 [Full]

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : hexane

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 294.1 microgram/ml

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : hexane

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 396.5 microgram/ml

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : asiatic acid

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 33.1 microgram/ml (67.7 micromolar) - Of particular interest is the potent inhibitory effect of asiatic acid on CYP2C9 (Ki = 9.1 microgram/ml)

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : asiatic acid

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 67.9 microgram/ml (138.9 micromolar)

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : asiatic acid

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : Male
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 53.6 microgram/ml (109.7 micromolar)

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : asiaticoside

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 1,070.2 microgram/ml (1,115.8 micromolar)

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : asiaticoside

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = > 1,500 microgram/ml (> 1,563.9 micromolar)

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : asiaticoside

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = > 1,500 microgram/ml (1,563.9 micromolar)

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : madecassic acid

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 40.8 microgram/ml (80.8 micromolar)

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

Part Used : ไม่ระบุ
Activity : DRUG INTERACTION

Solvent/Active Compound : madecassic acid

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : -

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : -
Dose/Conc.(drug) : -

Result : Positive

Remark : - IC50 = 30.7 microgram/ml (60.8 micromolar)

Note : - CYP2C9 was more susceptible to inhibitory effects by C. asiatica extracts compared to CYP2D6 and CYP3A4.

หน้า 1 2 3 4

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