ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : -

Activity : DRUG INTERACTION

Solvent/Active Compound : madecassoside

Type of experiment : in vivo

Type of animal : rat

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : Oral administration

Dose/Conc.(herb) : 100 mg/kg

Duration : single dose

Type of interaction : Pharmacokinetics

Interaction with drug : Probenecid*/Benemid

Dose/Conc.(drug) : -

Result : Positive

Remark :

Note : The combination with either digoxin or probenecid significantly attenuated the excretion of madecassoside as parent from bile, indicating that P-glycoprotein and multi drug resistance associated protein might contribute to the hepatobiliary elimination of madecassoside.

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