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Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Phenytoin*/Diphenylhydantoin/DPHDose/Conc.(drug) : -Result : PositiveRemark : A combination of Centalla asiatica (CA) extract with antiepileptic drugs (AEDs) resulted in a reduction in the ED50 of CA extract and concomitant AEDS. The ED50 of intraperitoneally given phyenytoin, valproate and gabapentin, were found to be 13, 14, and 310 mg/kg BW, respectively, when given alone, whereas the corresponding values in the presence of CA extract were 5, 29 and 79 mg/kg BW.Note : Data incomplete
Part Used : ใบActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 500 mg/kgDuration : The anticonvulsant activity was assessed by the classical Maximal Electro Shock (MES) test at 1, 3, 6 and 24 h after drug administration.Type of interaction : PharmacodynamicsInteraction with drug : Phenytoin*/Diphenylhydantoin/DPHDose/Conc.(drug) : -Result : EquivocalRemark : Results: When Centella asiatica (CA) was combined with phenytoin, though seizure protection was seen, this effect was not statistically significant. When CA was combined with phenobarbitone, the protective activity of phenobarbitone declined from 50% to 0% (p < 0.05) at 3 h. When CA was combined with carbamazepine, significant seizure protection was seen only at 1 and 3 h (p < 0.05).Note : Data incomplete.
