Part Used : ไม่ระบุ
Activity : DRUG INTERACTION
Solvent/Active Compound : andrographolide sulfonate
Type of experiment : human
Type of animal : -
Type of study : Open trial
N(Total) : 64
N(Treatment) : 18
Sex : Both sex
Age : 28.9 +/- 11.6 yrs.
Route : Intravenous
Dose/Conc.(herb) : -
Duration : 7-10 days
Type of interaction : Pharmacokinetics
Interaction with drug : Immunoglobulin*/Antibody/Ig
Dose/Conc.(drug) : -
Remark : At 5 days post-medication, the myeloperoxidase, S100A8/A9, histone, and interleukin-6 levels were markedly lower in the combination therapy group compared with the conventional therapy group.
Note : Subject total: hand, foot, and mouth disease (HFMD) patients who received conventional therapy (included decreasing intracranial hypertension, conscious sedation, reducing temperature, and applying glucocorticoids and immunoglobulin; n=28), patients who received combination therapy (andrographolide sulfonate plus conventional therapy) (n=18) and healthy control group (n=18).
