Part Used : -
Activity : DRUG INTERACTION
Solvent/Active Compound : Andrographolide
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : 1-100 micromolar
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Testosterone
Dose/Conc.(drug) : -
Remark : Type of experiment = Caco-2 cell monolayers
Note : Andrographolide significantly down-regulates the mRNA level and protein level of CYP3A4, and inhibits nifedipine oxidation and testosterone 6 beta-hydroxylation.