Part Used : -
Activity : DRUG INTERACTION
Solvent/Active Compound : Andrographolide derivatives
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : 100 micromolar
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Zidovudine*/AZT/ZDV/Azidothymidine
Dose/Conc.(drug) : -
Remark : Type of experiment = human liver microsome
Note : Andrographolide derivatives showed inhibition capabilities towards UDP-glucuronyl transferase (UGT) 2B7 and human liver microsome-catalyzed AZT glucuronidation.