ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : -

Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : Andrographolide

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : 1-100 micromolar

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : Nifedipine

Dose/Conc.(drug) : -

Result : Positive

Remark : Type of experiment = Caco-2 cell monolayers

Note : Andrographolide significantly down-regulates the mRNA level and protein level of CYP3A4, and inhibits nifedipine oxidation and testosterone 6 beta-hydroxylation.

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