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ACANTHACEAE Andrographis paniculata (Burm.f.) Wall. ex Nees

Synonym

none ...

Thai / English name

ฟ้าทะลายโจร*

[1-1] of 1 article(s) found

หน้า 1

[1] THE EFFECTS OF ANDROGRAPHIS PANICULATA ON THE PHARMACOKINETICS OF MIDAZOLAM IN NORMAL HEALTHY VOLUNTEERS.
POTJANEE SOONTARA,MALINEE WONGNAWA,WIBOOL RIDITID,ET AL.
THAI J PHARMACOL 2011 Vol.33(SUPPL 1),75 481650 [Abstract]

Part Used : -
Activity : CYP3A4 INHIBITION

Solvent/Active Compound : -

Type of experiment : human
Type of animal : -

Type of study : Open trial

N(Total) : 12
N(Treatment) : 12

Sex : Male
Age : -

Route : Oral administration
Dose/Conc.(herb) : 4 capsules of 250 mg A. paniculata, 3 times/day

Duration : 7 days
Type of interaction : Pharmacokinetics

Interaction with drug : Midazolam*/Versed/Dormicum
Dose/Conc.(drug) : -

Result : Negative

Remark : Subjects = healthy volunteers

Note : A. paniculata did not change mean pharmacokinetic parameters (Cmax, Tmax, AUC0-12h, AUC0-infinity, T1/2, C1/F) of oral midazolam. Thus, no clinically relevant CYP3A4 inhibition after in healthy volunteers was suggested. Data incomplete

Part Used : -
Activity : CYP3A4 INHIBITION

Solvent/Active Compound : -

Type of experiment : human
Type of animal : -

Type of study : Cross over

N(Total) : 12
N(Treatment) : 12

Sex : Male
Age : -

Route : Oral administration
Dose/Conc.(herb) : 4 capsules of 250 mg A. paniculata, 3 times/day

Duration : 7 days
Type of interaction : Pharmacokinetics

Interaction with drug : Midazolam*/Versed/Dormicum
Dose/Conc.(drug) : -

Result : Negative

Remark : Subjects = healthy volunteers

Note : A. paniculata did not change mean pharmacokinetic parameters (Cmax, Tmax, AUC0-12h, AUC0-infinity, T1/2, C1/F) of oral midazolam. Thus, no clinically relevant CYP3A4 inhibition after in healthy volunteers was suggested. Data incomplete

หน้า 1

EN

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