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Part Used : -Activity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Open trialN(Total) : 12N(Treatment) : 12Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : 4 capsules of 250 mg A. paniculata, 3 times/dayDuration : 7 daysType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : NegativeRemark : Subjects = healthy volunteersNote : A. paniculata did not change mean pharmacokinetic parameters (Cmax, Tmax, AUC0-12h, AUC0-infinity, T1/2, C1/F) of oral midazolam. Thus, no clinically relevant CYP3A4 inhibition after in healthy volunteers was suggested. Data incomplete
Part Used : -Activity : CYTOCHROME P-450 INHIBITIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 12N(Treatment) : 12Sex : MaleAge : -Route : Oral administrationDose/Conc.(herb) : 4 capsules of 250 mg A. paniculata, 3 times/dayDuration : 7 daysType of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : -Result : NegativeRemark : Subjects = healthy volunteersNote : A. paniculata did not change mean pharmacokinetic parameters (Cmax, Tmax, AUC0-12h, AUC0-infinity, T1/2, C1/F) of oral midazolam. Thus, no clinically relevant CYP3A4 inhibition after in healthy volunteers was suggested. Data incomplete