Part Used : น้ำจากผล
Activity : EFFECTS ON PHARMACOKINETIC
Solvent/Active Compound : -
Type of experiment : in vivo
Type of animal : rat
N(Total) : -
N(Treatment) : -
Route : Oral administration
Dose/Conc.(herb) : 3 mL/kg/day
Duration : 1 week
Type of interaction : Pharmacokinetics
Interaction with drug : Nitrendipine
Dose/Conc.(drug) : 10 mg/kg
Remark : Type of experiment: *Rat in situ single-pass intestinal perfusion
- There was a significant increase in effective permeability, absorption rate constant and fraction of drug absorbed in the pretreated group when compared with the control group, probably due to inhibition of the P-glycoprotein-mediated efflux of the drug by pomegranate juice (PJ). In comparison with control, PJ treatment significantly increased the area under the concentration-time curve of oral nitrendipine. The peak plasma concentration of nitrendipine was also significantly increased by PJ. However, elimination half-life of nitrendipine was not altered significantly in both PJ co-administered and pretreated groups. These results suggest that PJ inhibits the intestinal metabolism of nitrendipine without inhibiting the hepatic metabolism in rats.