ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : เนื้อหุ้มเมล็ด

Activity : MUSCLE EFFECTS(UNSPECIFIED)

Solvent/Active Compound : pomegranate juice

Type of experiment : human

Type of animal : -

Type of study : Case report

N(Total) : 1

N(Treatment) : 1

Sex : Male

Age : 48 yrs.

Route : Oral administration

Dose/Conc.(herb) : -

Duration : 3 wk

Type of interaction : Pharmacodynamics

Interaction with drug : Rosuvastatin

Dose/Conc.(drug) : -

Result : Positive

Remark : Pomegranate may increase the risk for rhabdomyolysis during statin therapy, as a result of intestinal CYP3A4 inhibition and increased absorption of active drugs, as commonly reported for grapefruit juice. One case report described a 48 y old man who developed rhabdomyolysis 3 wk after he began drinking pomegranate juice while taking ezetimibe and rosuvastatin for familial hypercholesterolemia.

Note : Data from review

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