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PUNICACEAE Punica granatum L. var. granatum

Synonym

none ...

Thai / English name

ทับทิม*

[1-2] of 2 article(s) found

หน้า 1

[1] EFFECTS OF POMEGRANATE JUICE ON HUMAN CYTOCHROME P450 3A (CYP3A) AND CARBAMAZEPINE PHARMACOKINETICS IN RATS.
HIDAKA M,OKUMURA M,FUJITA K,ET AL.
DRUG METAB DISPOS 2005 Vol.33(5),644-8 372401 [Abstract]

Part Used : น้ำจากผล
Activity : DRUG INTERACTION

Solvent/Active Compound : -

Type of experiment : in vivo
Type of animal : rat

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : Oral administration
Dose/Conc.(herb) : 2 mL

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Carbamazepine*/CBZ
Dose/Conc.(drug) : 50 mg/kg

Result : Positive

Remark : Pomegranate juice alters the carbamazepine pharmacokinetics in rats.

Note : Data incomplete

[2] EFFECTS OF POMEGRANATE JUICE ON HUMAN CYTOCHROME P450 3A (CYP3A) AND CARBAMAZEPINE PHARMACOKINETICS IN RATS.
HIDAKA M,OKUMURA M,FUJITA K-I,ET AL.
DRUG METAB DISPOS 2005 Vol.33(5),644-8 373510 [Abstract]

Part Used : น้ำจากผล
Activity : DRUG INTERACTION

Solvent/Active Compound : -

Type of experiment : in vitro
Type of animal : -

Type of study : -

N(Total) : -
N(Treatment) : -

Sex : -
Age : -

Route : -
Dose/Conc.(herb) : 25 microlit (5.0%v/v)

Duration : -
Type of interaction : Pharmacokinetics

Interaction with drug : Carbamazepine*/CBZ
Dose/Conc.(drug) :

Result : Positive

Remark : Type of experiment: Human liver microsome Addition of 25 microl (5% v/v) of pomegranate juice resulted in almost complete inhibition of the carbamazepine 10,11-epoxidase activity of human CYP3A (1.8%).

Note : Data incomplete

หน้า 1

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