| Synonym |
| Thai / English name |
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Single-blind trialN(Total) : 13N(Treatment) : 13Sex : MaleAge : 35 +/- 8 yrs.Route : Oral administrationDose/Conc.(herb) : 8 ozDuration : -Type of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : 2 mg (i.v.)Result : NegativeRemark : Subjects: healthy male volunteers participated in a randomized, single-dose, 5-way crossover study, with 1 week elapsing between trials. The 5 treatment groups were: 1. Intravenous (IV) midazolam (2 mg) preceded by water 2. Oral midazolam (6 mg) preceded by water 3. IV midazolam (2 mg) preceded by pomegranate juice 4. Oral midazolam (6 mg) preceded by pomegranate juice 5. Oral midazolam (6 mg) preceded by grapefruit juice Results: Pretreatment of volunteer subjects with pomegranate juice did not alter the elimination half-life, volume of distribution, or clearance of intravenous midazolam (2 mg). Administration of pomegranate juice also did not affect Cmax, total area under the curve (AUC), or clearance of oral midazolam (6 mg).
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 13N(Treatment) : 13Sex : MaleAge : 35 +/- 8 yrs.Route : Oral administrationDose/Conc.(herb) : 8 ozDuration : -Type of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : 2 mg (i.v.)Result : NegativeRemark : Subjects: healthy male volunteers participated in a randomized, single-dose, 5-way crossover study, with 1 week elapsing between trials. The 5 treatment groups were: 1. Intravenous (IV) midazolam (2 mg) preceded by water 2. Oral midazolam (6 mg) preceded by water 3. IV midazolam (2 mg) preceded by pomegranate juice 4. Oral midazolam (6 mg) preceded by pomegranate juice 5. Oral midazolam (6 mg) preceded by grapefruit juice Results: Pretreatment of volunteer subjects with pomegranate juice did not alter the elimination half-life, volume of distribution, or clearance of intravenous midazolam (2 mg). Administration of pomegranate juice also did not affect Cmax, total area under the curve (AUC), or clearance of oral midazolam (6 mg).
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Single-blind trialN(Total) : 13N(Treatment) : 13Sex : MaleAge : 35 +/- 8 yrs.Route : Oral administrationDose/Conc.(herb) : 8 ozDuration :Type of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : 6 mg (p.o.)Result : NegativeRemark : Subjects: healthy male volunteers participated in a randomized, single-dose, 5-way crossover study, with 1 week elapsing between trials. The 5 treatment groups were: 1. Intravenous (IV) midazolam (2 mg) preceded by water 2. Oral midazolam (6 mg) preceded by water 3. IV midazolam (2 mg) preceded by pomegranate juice 4. Oral midazolam (6 mg) preceded by pomegranate juice 5. Oral midazolam (6 mg) preceded by grapefruit juice Results: Pretreatment of volunteer subjects with pomegranate juice did not alter the elimination half-life, volume of distribution, or clearance of intravenous midazolam (2 mg). Administration of pomegranate juice also did not affect Cmax, total area under the curve (AUC), or clearance of oral midazolam (6 mg).
Part Used : น้ำจากผลActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross overN(Total) : 13N(Treatment) : 13Sex : MaleAge : 35 +/- 8 yrs.Route : Oral administrationDose/Conc.(herb) : 8 ozDuration :Type of interaction : PharmacokineticsInteraction with drug : Midazolam*/Versed/DormicumDose/Conc.(drug) : 6 mg (p.o.)Result : NegativeRemark : Subjects: healthy male volunteers participated in a randomized, single-dose, 5-way crossover study, with 1 week elapsing between trials. The 5 treatment groups were: 1. Intravenous (IV) midazolam (2 mg) preceded by water 2. Oral midazolam (6 mg) preceded by water 3. IV midazolam (2 mg) preceded by pomegranate juice 4. Oral midazolam (6 mg) preceded by pomegranate juice 5. Oral midazolam (6 mg) preceded by grapefruit juice Results: Pretreatment of volunteer subjects with pomegranate juice did not alter the elimination half-life, volume of distribution, or clearance of intravenous midazolam (2 mg). Administration of pomegranate juice also did not affect Cmax, total area under the curve (AUC), or clearance of oral midazolam (6 mg).
