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Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : SoymilkType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 4.0 g/kg of soymilk powdersDuration : *Type of interaction : PharmacokineticsInteraction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyADose/Conc.(drug) : -Result : PositiveRemark : Result: soymilk significantly decreased the Cmax of CSP by 64.5%, and reduced the AUC0-540 by 64.9%. Mechanism studies revealed that the activities of P-gp and CYP3A4 were induced by soymilk. Conculsion, ingestion of soymilk significantly activated the functions of P-gp and CYP3A.Note : Cyclosporine (CSP), an immunosuppressant agent, is a substrate of P-gp and CYP3A4. *Duration: CSP was given to the rats at 2.5 mg/kg with and without a concomitant dose of miso or soymilk powders in crossover designs. Blood samples were withdrawn via cardiopuncture at 20, 40, 60, 180, 300 and 540 min after dosing with CSP.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : MisoType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 2.0 g/kg of misoDuration : *Type of interaction : PharmacokineticsInteraction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyADose/Conc.(drug) : -Result : PositiveRemark : Result: Miso significantly decreased the Cmax of CSP by 78.3%, and reduced the AUC0-540 by 78.3%, respectively. Mechanism studies revealed that the activities of P-gp and CYP3A4 were induced by miso. Conclusion, ingestion of miso significantly activated the functions of P-gp and CYP3A.Note : Cyclosporine (CSP), an immunosuppressant agent, is a substrate of P-gp and CYP3A4. *Duration: CSP was given to the rats at 2.5 mg/kg with and without a concomitant dose of miso or soymilk powders in crossover designs. Blood samples were withdrawn via cardiopuncture at 20, 40, 60, 180, 300 and 540 min after dosing with CSP.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : daidzeinType of experiment : humanType of animal : -Type of study : Single-blind trialN(Total) : 20 (M/F = 10/10)N(Treatment) : 10Sex : Both sexAge : 22-28 yrs. (mean 25)Route : Oral administrationDose/Conc.(herb) : 200 mg daidzein twice daily for 10 days and on day 12, the test group received 200 mg daidzein with 100 mg theophylline.Duration : 10 daysType of interaction : PharmacokineticsInteraction with drug : Theophylline*/AminophyllineDose/Conc.(drug) : -Result : PositiveRemark : Result: Comparing the kinetics parameters of theophylline of day 1 (without co-medication) with those of day 12 (10-day daidzein), the AUC (0-48), AUC (0- infinity), C(max) and t(1/2) were significantly increased by 33.57+/-21.75% (Cl, 1.21-1.46, P<0.05), 33.77+/-21.45% (Cl, 1.20-1.46, P<0.05), 23.54+/-16.93% (Cl, 1.23-1.52, P<0.05) and 41.39+/-45.92% (t=-3.19, P=0.011), respectively. The pharmacokinetic parameters of theophylline within the placebo group showed no statistically significant difference (P >0.05).Note : Type of study: A single-blind, placebo-controlled, parallel study
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : non specifiedN(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Levothyroxine*/T4/L-ThyroxineDose/Conc.(drug) :Result : PositiveRemark : In particular, certain foods and drinks affect the absorption of levothyroxine: in particular, dietary fibers, grapes, soybeans, papaya and coffee reduce the absorption of the drug.Note : Data from review
Part Used : ไม่ระบุActivity : DRUG INTERACTIONSolvent/Active Compound : -Type of experiment : humanType of animal : -Type of study : Cross-sectionN(Total) : 233N(Treatment) : -Sex : FemaleAge : -Route : Oral administrationDose/Conc.(herb) : -Duration : -Type of interaction : PharmacokineticsInteraction with drug : Tamoxifen*/TAMDose/Conc.(drug) : -Result : PositiveRemark : The study identified use of 35 different typed of complimentary alternative medicine products and seven of these could potentially increase the risk of breast cancer or interact with tamoxifen or aromatase inhibitiors: soy, garlic, Ginkgo biloba, Echinacea, ginseng, velerian and phytoestrogens (excluding soy).Note : Data incomplete Subject were consecutive breast cancer patients
