Part Used : ไม่ระบุ
Activity : P-GLYCOPROTEIN INHIBITION
Solvent/Active Compound : Genistein
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : -
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Tamoxifen*/TAM
Dose/Conc.(drug) : -
Remark : No clinical reports, and conflicting evidence between effects of genistein, an isolated ingredient, and the total extract of soya. Genistein inhibits various CYP enzymes and P-gp, but soya extract does not affect CYP3A4. Theoretical considerations suggest avoidance with HRT, also tamoxifen and other treatments for breast cancer.
Note : Data incomplete, data from review article.