ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ไม่ระบุ

Activity : CYTOCHROME P-450 INHIBITION

Solvent/Active Compound : Genistein

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : -

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : Tamoxifen*/TAM

Dose/Conc.(drug) : -

Result : Positive

Remark : No clinical reports, and conflicting evidence between effects of genistein, an isolated ingredient, and the total extract of soya. Genistein inhibits various CYP enzymes and P-gp, but soya extract does not affect CYP3A4. Theoretical considerations suggest avoidance with HRT, also tamoxifen and other treatments for breast cancer.

Note : Data incomplete, data from review article.

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