| Synonym |
| Thai / English name |
Part Used : เมล็ดActivity : CYP3A4 INDUCTIONSolvent/Active Compound : SoymilkType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 4.0 g/kg of soymilk powdersDuration : *Type of interaction : PharmacokineticsInteraction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyADose/Conc.(drug) : -Result : PositiveRemark : Result: soymilk significantly decreased the Cmax of CSP by 64.5%, and reduced the AUC0-540 by 64.9%. Mechanism studies revealed that the activities of P-gp and CYP3A4 were induced by soymilk. Conculsion, ingestion of soymilk significantly activated the functions of P-gp and CYP3A.Note : Cyclosporine (CSP), an immunosuppressant agent, is a substrate of P-gp and CYP3A4. *Duration: CSP was given to the rats at 2.5 mg/kg with and without a concomitant dose of miso or soymilk powders in crossover designs. Blood samples were withdrawn via cardiopuncture at 20, 40, 60, 180, 300 and 540 min after dosing with CSP.
Part Used : เมล็ดActivity : CYP3A4 INDUCTIONSolvent/Active Compound : MisoType of experiment : in vivoType of animal : ratType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : Oral administrationDose/Conc.(herb) : 2.0 g/kg of misoDuration : *Type of interaction : PharmacokineticsInteraction with drug : Ciclosporin*/Cyclosporin/Cyclosporin A/Cyclosporine/CsA/CyADose/Conc.(drug) : -Result : PositiveRemark : Result: Miso significantly decreased the Cmax of CSP by 78.3%, and reduced the AUC0-540 by 78.3%, respectively. Mechanism studies revealed that the activities of P-gp and CYP3A4 were induced by miso. Conclusion, ingestion of miso significantly activated the functions of P-gp and CYP3A.Note : Cyclosporine (CSP), an immunosuppressant agent, is a substrate of P-gp and CYP3A4. *Duration: CSP was given to the rats at 2.5 mg/kg with and without a concomitant dose of miso or soymilk powders in crossover designs. Blood samples were withdrawn via cardiopuncture at 20, 40, 60, 180, 300 and 540 min after dosing with CSP.
