| Synonym |
| Thai / English name |
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Peanut extractType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 6 mg peanut extract + 15 microgram cholera toxin for 3 consecutive days/weekDuration : 3 weeksType of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : 1 mg/kgResult : PositiveRemark : Administration of diclofenac before peanut extract (PE) + cholera toxin (CT) expsosure resulted in significant increases of serum levels of PE-specific lgG1 and lgE. Furthermore, mMCP-1, a measure for mast cell degranulation in vivo, was enhanced by diclofenac upon an oral chanllenge with PE. When mice were treated with 0 or 25 mg/kg diclofenac and PE in the absence of CT, no PE- specific antibodied could be detected, indicating that diclofenac at this dose is not able to elicit an allergic response in the absence of the adjuvant CT.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Peanut extractType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 6 mg peanut extract + 15 microgram cholera toxin for 3 consecutive days/weekDuration : 3 weeksType of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : 10 mg/kgResult : PositiveRemark : Administration of diclofenac before peanut extract (PE) + cholera toxin (CT) expsosure resulted in significant increases of serum levels of PE-specific lgG1 and lgE. Furthermore, mMCP-1, a measure for mast cell degranulation in vivo, was enhanced by diclofenac upon an oral chanllenge with PE. When mice were treated with 0 or 25 mg/kg diclofenac and PE in the absence of CT, no PE- specific antibodied could be detected, indicating that diclofenac at this dose is not able to elicit an allergic response in the absence of the adjuvant CT.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Peanut extractType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 6 mg peanut extract + 15 microgram cholera toxin for 3 consecutive days/weekDuration : 3 weeksType of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : 25 mg/kgResult : PositiveRemark : Administration of diclofenac before peanut extract (PE) + cholera toxin (CT) expsosure resulted in significant increases of serum levels of PE-specific lgG1 and lgE. Furthermore, mMCP-1, a measure for mast cell degranulation in vivo, was enhanced by diclofenac upon an oral chanllenge with PE. When mice were treated with 0 or 25 mg/kg diclofenac and PE in the absence of CT, no PE- specific antibodied could be detected, indicating that diclofenac at this dose is not able to elicit an allergic response in the absence of the adjuvant CT.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Peanut extractType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 6 mg peanut extract for 3 consecutive/weekDuration : 3 weeksType of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : 1 mg/kgResult : NegativeRemark : Administration of diclofenac before peanut extract (PE) + cholera toxin (CT) expsosure resulted in significant increases of serum levels of PE-specific lgG1 and lgE. Furthermore, mMCP-1, a measure for mast cell degranulation in vivo, was enhanced by diclofenac upon an oral chanllenge with PE. When mice were treated with 0 or 25 mg/kg diclofenac and PE in the absence of CT, no PE- specific antibodied could be detected, indicating that diclofenac at this dose is not able to elicit an allergic response in the absence of the adjuvant CT.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Peanut extractType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 6 mg peanut extract for 3 consecutive/weekDuration : 3 weeksType of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : 10 mg/kgResult : NegativeRemark : Administration of diclofenac before peanut extract (PE) + cholera toxin (CT) expsosure resulted in significant increases of serum levels of PE-specific lgG1 and lgE. Furthermore, mMCP-1, a measure for mast cell degranulation in vivo, was enhanced by diclofenac upon an oral chanllenge with PE. When mice were treated with 0 or 25 mg/kg diclofenac and PE in the absence of CT, no PE- specific antibodied could be detected, indicating that diclofenac at this dose is not able to elicit an allergic response in the absence of the adjuvant CT.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Peanut extractType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 6 mg peanut extract for 3 consecutive days/weekDuration : 3 weeksType of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : 25 mg/kgResult : NegativeRemark : Administration of diclofenac before peanut extract (PE) + cholera toxin (CT) expsosure resulted in significant increases of serum levels of PE-specific lgG1 and lgE. Furthermore, mMCP-1, a measure for mast cell degranulation in vivo, was enhanced by diclofenac upon an oral chanllenge with PE. When mice were treated with 0 or 25 mg/kg diclofenac and PE in the absence of CT, no PE- specific antibodied could be detected, indicating that diclofenac at this dose is not able to elicit an allergic response in the absence of the adjuvant CT.
Part Used : เมล็ดActivity : DRUG INTERACTIONSolvent/Active Compound : Peanut extractType of experiment : in vivoType of animal : mouseType of study : -N(Total) : -N(Treatment) : -Sex : -Age : -Route : IntraperitonealDose/Conc.(herb) : 1 mg peanut extractDuration : 3 daysType of interaction : PharmacokineticsInteraction with drug : DiclofenacDose/Conc.(drug) : 1 mg/kg, 2 h before each oral PE exposureResult : PositiveRemark : Administration of diclofenac before oral exposure to peanut extract (PE) did not abrogate oral tolerance induction, as PE-specific antibodies in serum were comparably low in diclofenac treated and vehicle-treated tolerized mice. In addition, cytokine levels in the supernatant of cultured splenocytes from PE-tolerized, diclofenac-treated mice were significantly lower compared with those in splenocyte cultures of non-tolerized mice. Noticeably, the ex vivo PE specific cytokine levels of diclofenac-treated tolerized mice were significantly higher compared with vehicle-treated tolerized mice, except in the case of lL-4.
