Part Used : ใบ
Activity : EFFECTS ON PHARMACOKINETIC
Solvent/Active Compound : Deoxyelephantopin
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : 0.01-10 micromol
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Testosterone
Dose/Conc.(drug) : -
Remark : Deoxyelephantopin weakly inhibits the metabolism of testosterone (IC50 = 14.00 micromolar). Deoxyelephantopin inhibition the metabolism of testosterone (>50%) at concentrations of 10 micromolar and above as compared with ketoconazole, more than 50% of the activity was abolished at 0.5 micromolar and above.