Part Used : ใบ
Activity : EFFECTS ON PHARMACOKINETIC
Solvent/Active Compound : Deoxyelephantopin
Type of experiment : in vitro
Type of animal : -
N(Total) : -
N(Treatment) : -
Route : -
Dose/Conc.(herb) : 0.01-10 micromolar
Duration : -
Type of interaction : Pharmacokinetics
Interaction with drug : Midazolam*/Versed/Dormicum
Dose/Conc.(drug) : -
Remark : Deoxyelephantopin was also found to inhibit metabolism of midazolam weakly between 0.01 and 10 micromolar range of concentration (IC50 = 46.18 micromolar). Deoxyelephantopin inhibited the metabolism of midazolam (>50%) at concentrations of 50 micromolar and above as compared with ketocozole, the inhibition was more pronounced, at concentrations 0.5 micromolar and above.