ฐานข้อมูลอันตรกิริยาระหว่างสมุนไพรกับยาแผนปัจจุบัน

Part Used : ผล

Activity : CYP2D6 INHIBITION

Solvent/Active Compound : ethanol

Type of experiment : in vitro

Type of animal : -

Type of study : -

N(Total) : -

N(Treatment) : -

Sex : -

Age : -

Route : -

Dose/Conc.(herb) : -

Duration : -

Type of interaction : Pharmacokinetics

Interaction with drug : -

Dose/Conc.(drug) : -

Result : Positive

Remark : The selective inhibitor quinidine showed the most potent inhibitory activity on CYP2D6 activity with mean IC50 of 0.97 microgram/mL. DM, DL and PI showed the highest inhibitory activities (mean IC50 2.93-9.57 microgram/mL). The potency of inhibitory activity of DM was comparable to that of quinidine (p > 0.05). PC, GM and ZO exhibited moderate potencies (mean IC50 23.40-31.32 microgram/mL), and MF and AL exhibited relatively low potencies (mean IC50 195.83 and 313.51 microgram/mL, respectively). (substrate: dextromethorphan)

Note : Piper chaba (PC), Dioscroea membranacea (DI), Dracaenal oureiri (DG), Atractylodes lancea (AL), Plumbago indica (PI), Zingiber officinale (ZO), Myristica fragrans (MF), Garcinia mangostana (GM).

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